Lamin B Receptor Function

Lamin b1 is involved in the processes of dna replication cell cycle progression and gene silencing through binding to lads.

Lamin b receptor function. Lamin b receptor lbr is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. Abstract lamin b receptor lbr is an integral protein of the inner nuclear membrane containing a hydrophilic n terminal end protruding into the nucleoplasm eight hydrophobic segments that span the membrane and a short nucleoplasmic c terminal tail. In addition we showed that knockdown of lbr induces cellular senescence in tig 7 cells 20. We demonstrate that human lbr is essential for cholesterol synthesis.

Lbr shows a decrease inlbr. Several lbr mutations implicated in human. Two seemingly unrelated functions. We show here that the diffusional mobility of full length lbr exhibits significant regional variation along the nuclear envelope consistent with the.

In our previous studies we have shown that lamin b receptor lbr an integral inner nuclear membrane protein that regulates heterochromatin organization plays crucial roles in cellular senescence. Lamin b receptor has been shown to interact with cbx3 and cbx5. Lamin b receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β journal of cell science. Among the inm integral proteins lamin b receptor lbr is the best studied.

Consistent with this we have previously found that lamin b receptor lbr a nuclear membrane protein that regulates heterochromatin organization 18 shows aberrant localization and down regulation in senescent cells 19 20. It preferentially binds to lamin b1 through a rs domain and a tudor domain both located at the n terminal end. Two seemingly unrelated functions have been attributed to lbr. Lbr also interacts with long non coding rna xist in mouse cells and potentially assist the spreading xist across x chromosome.